PoreDesigner for tuning solute selectivity in a robust and highly permeable outer membrane pore. High-density reconstitution of functional water channels into vesicular and planar block copolymer membranes. Membrane protein insertion into and compatibility with biomimetic membranes. Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z. Kumar, M., Grzelakowski, M., Zilles, J., Clark, M. This approach could provide high performance alternatives in the challenging sub-nanometre to few-nanometre size range. These biomimetic membranes demonstrate water permeability that is 20–1,000 times greater than that of commercial membranes and 1.5–45 times greater than that of the latest research membranes with comparable molecular exclusion ratings. These MP-BCP nanosheet membranes maintain the molecular selectivity of the three types of β-barrel MP channels used, with pore sizes of 0.8 nm, 1.3 nm, and 1.5 nm. We then integrate these hybrid materials into scalable MP-BCP biomimetic membranes. Here, we demonstrate a two-hour organic solvent method to develop 2D crystals and nanosheets of highly packed pore-forming MPs in block copolymers (BCPs). However, successful integration of MPs into manufactured membranes has remained a significant challenge. Biological membranes are ideal for separations as they provide high permeability while maintaining high solute selectivity due to the presence of specialized membrane protein (MP) channels.

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